Verified Document

Savior Baby Lit Review Research Paper

Preimplantation Genetic Diagnosis: State of the Art Preimplantation genetic diagnosis (PGD) is used to analyze embryos genetically before their transfer into the uterus and offers couples at risk the chance to have an unaffected child, without facing termination of pregnancy. Embryos are obtained by in vitro fertilization with intracytoplasmic sperm injection (ICSI), and are biopsied mostly on day 3; blastocyst biopsy is mentioned as a possible alternative; the genetic analysis is performed on one or two blastomeres, by fluorescent in situ hybridization (FISH) for cytogenetic diagnosis, or polymerase chain reaction (PCR) for moleculardiagnosis (Basille, et al., 2009). PGD requires a close collaboration between obstetricians, fertility specialists, IVF laboratory and human geneticists. It needs intensive effort, expensive techniques and is demanding for the patients, but it offers tremendous opportunity for couples whose previous child has exhibited genetic abnormalities.

Children as Hematopoietic Stem Cell Donors

This article isn't directly related to PGD but, based on the last article, it seemed relevant to find information on the ethical implications that are relevant to using PGD to generate umbilical cords for older siblings. Children often serve as hematopoietic stem cell donors, most commonly for their siblings. HLA-matched biological siblings are generally preferred as donors because of reduced risks of transplant-related complications as compared with unrelated donors (Committee on Bioethics, 2010)....

Whereas bone marrow transplant and peripheral blood might be controversial, the umbilical cords are relatively less of an ethical challenge. PGD could actually ensure that the umbilical cord meets the HLA properties of their siblings and could serve as a viable option for a variety of diseases. In 1990, Abe and Mary Ayala became the first successful publicized case in which a family sought to conceive a child (Marissa) to save another child (Anissa) and there have been later cases where PGD contributed to the HLA matching.
Preimplantation genetic diagnosis at 20 years

PGD has evolved into not simply an earlier extension of traditional prenatal genetic diagnosis, but a modality offering novel indications. PGD can be applied for any Mendelian disorder whose location is known, using linkage analysis even when the causative mutation is not known. More than 200 different conditions have been tested, with high accuracy and safety (Johnson, 2010). The advancements in the field have and the new capabilities that are available have made many call for a new approach to the ethical considerations that are now feasible.

SAVIOR SIBLINGS, PARENTING AND THE MORAL VALORIZATION OF CHILDREN

The reason…

Sources used in this document:
Works Cited

Basille, C., Frydman, R., Abdelwahab, E., Laetitia, H., Renato, F., Gerard, T., . . . Achour, N. (2009). Preimplantation genetic diagnosis: State of the art. European Journal of Obstetrics & Gynecology and Reproductive Biology, 9-13.

Committee on Bioethics. (2010). Children as Hematopoietic Stem Cell Donors. Pediatrics, VOLUME 125 / ISSUE 2.

Johnson, J. (2010). Preimplantation genetic diagnosis at 20 years. Prenatal Diagnosis, 682-695.

Renwick, P., & Ogilvie, C. (2007). Preimplantation genetic diagnosis for monogenic diseases: overview and emerging issues. Expert Rev. Mol. Diagn., 33-44.
Cite this Document:
Copy Bibliography Citation

Related Documents

Bioethics: Fetal Tissue Research and Transplantation in
Words: 1348 Length: 4 Document Type: Essay

Bioethics: Fetal tissue research and transplantation in the scientific research community has grown to attract huge debate and controversies since the late 1980s when doctors began to conclude that the bodies of unborn babies could be used in tackling certain diseases. This aspect continued to develop as scientists proposed that fetal tissue can also be used in helping infertile couples to have children. This is largely because these tissues can be

Bioethics: Transplant Case Study Thorough Examination of
Words: 3170 Length: 10 Document Type: Term Paper

Bioethics: Transplant Case Study thorough examination of any "real life" ethical question involves the examination of all of the issues at hand. It is no different for issues of problematic bioethics. Thus, in consideration of the famous "botched heart transplant story," one must ask the salient questions, "what went wrong," "what should have been done," and "what can one do to insure that this issue will be less likely to

Bioethics Definitions Autonomy: "Personal Rule
Words: 1332 Length: 3 Document Type: Essay

If the lungs are forced to keep breathing, such people can continue to digest food, excrete waste, and even bear children" (Cline 2013). In the case of total brain death, "the cessation of functioning in those parts of the brain responsible for consciousness and higher reasoning powers is necessary for the death of the 'person' aspect of the brain and body" has occurred (Cline 2013). Q4. Belmont report principles The 1979

Bioethics -- Assisted Suicide Three-Step Model-Based Ethical
Words: 1183 Length: 4 Document Type: Essay

Bioethics -- Assisted Suicide THREE-STEP MODEL-BASED ETHICAL ANALYSIS OF ASSISTED SUICIDE Introduction Assisted suicide, or euthanasia, is a controversial topic because it contradicts one of the most fundamental values of American and other Judeo-Christian teaching: namely, that human life is sacred. Similarly, in medicine, euthanasia violates the Hippocratic Oath, according to which the first ethical obligation of doctors is to do no harm. However, in modern society, that traditional prohibition against assisting others

Bioethics Physician-Assisted Suicide Is Illegal
Words: 827 Length: 2 Document Type: Research Paper

Religioustolerance.org/euthanas.htm Stem cell research is a new field, one that was not yet envisioned by the apostles or other authors of the Bible. As a revolutionary form of healing, stem cell research and practice may not be entirely in conflict with scripture. Jesus was the ultimate healer, and therefore stem cell research can be viewed as an extension of this gift from God. Moreover, Luke himself was a physician who would

Bioethics From a Utilitarian Perspective,
Words: 1407 Length: 5 Document Type: Thesis

Indeed, by an active participation of the patient, we also tacitly understand that the patient is also fully informed about the course of the medical treatment, about his condition and even about the way scientific research affects his or her illness. On the other hand, this model has several important setbacks. First of all, it is a matter of time and usually a physician is involved with more than one

Sign Up for Unlimited Study Help

Our semester plans gives you unlimited, unrestricted access to our entire library of resources —writing tools, guides, example essays, tutorials, class notes, and more.

Get Started Now